Speaker A
My prolactin is at five nanograms per milliliter and probably now it's lower than that, frankly. And guess what? I have zero side effects, only benefits. If you talk to a well-studied, well-cultured endocrinologist, they are going to say
Lowering prolactin to ultra-low levels improved sexual function and libido with no side effects in a 40-year-old man on TRT.
Key Takeaways
- Low prolactin in males is generally not harmful and may improve sexual function.
- Prolactin reduction can be achieved safely with P5P and Chandra supplements.
- Improved libido and reduced refractory period are possible benefits of low prolactin.
- Estrogen receptor modulation in the pituitary is key to controlling prolactin secretion.
- Low prolactin symptoms are often confused with pituitary or testosterone issues.
What the video covers
- The creator lowered his prolactin to around 5 ng/mL, possibly even lower, and experienced no side effects, only benefits.
- Endocrinologists agree low prolactin in males is not associated with disease.
- Low prolactin often correlates with low testosterone due to pituitary dysfunction, not prolactin itself causing symptoms.
- Sexual function and refractory period improved significantly with lowered prolactin.
- Prolactin was lowered using P5P (active vitamin B6) supplementation and Chandra (Chandraka or Chandra Chinensis) to block estrogen-induced prolactin release.
- Chandra modulates estrogen receptor activity in the pituitary lactotropes, reducing prolactin secretion.
- Typical male prolactin levels are 10-15 ng/mL; the creator’s levels are well below that.
- The video includes lab results, explanations of mechanisms, and personal experience on TRT.
- The creator warns about potential neuropathy with high P5P doses in some individuals but does not experience this due to good GABA levels.
- The video also promotes Cortex Labs nootropic stacks with a discount code.
Chapters
- 00:00Introduction and Prolactin Levels Overview
- 01:20Lab Results and Personal Experience
- 03:25Sexual Function and Refractory Period Improvements
- 04:41P5P Supplementation to Lower Prolactin
- 05:40Chandra Supplement and Estrogen-Induced Prolactin Blockade
- 06:48Mechanism of Chandra on Estrogen Receptors
- 08:06Additional Hormonal and Mental Health Insights
- 15:23Conclusion and Product Promotion
Full Transcript — Download SRT & Markdown
Speaker A
the same thing when you discuss the notion of having low prolactin and whether or not low prolactin is a problem. They're going to say there is no disease associated with low levels of prolactin in males, but as this user
Speaker A
says here, did you ever find out? This is my issue now: low testosterone and low prolactin. My doctor has never seen it before, so of course I'm looking but finding nothing. Where the confusion actually sits with people thinking that
Speaker A
low prolactin somehow gives you low estrogen-like symptoms, which it definitely doesn't, and I'm going to show you my blood work here in a second, is that if one has naturally low prolactin, as is the case with this guy, he probably
Speaker A
has low testosterone as well, which means that the pituitary is not functioning correctly, which would be actually the big basis of symptoms in these cases and not the low [Music] prolactin. I'm going to show you my labs taken from 9:25, which is just like 7
Speaker A
days ago or so, where my prolactin is exceptionally low, and then I'm going to explain exactly how I feel and how I don't have side effects. All right, to kick this video off, look, you either owe me a like or you don't owe me a like, and
Speaker A
the way we're going to do this is we're going to flip this coin. If you get it right, you can move on. If you get it wrong, you owe your boy a like. Let's flip it. All right, tails. If you pick tails,
Speaker A
move on, all good, bro. But if you pick heads, you got it wrong. You owe your boy a like. Would truly appreciate it if you would sub to the channel, bro. I think you're going to love the content here, so
Speaker A
if you're watching, just hit the sub button and give it a chance. Also, again, the coupon for both of our nootropic stacks is still live. The code is 15. Now, that saves you 15% on both the Cortex nootropic stack and the Torque
Speaker A
stack. Please go look them up, read about what they do, read people's reviews on YouTube and elsewhere, go buy the stacks in the description of this video, use the code, save some money. So what better way to start this off than to just show you
Speaker A
my labs? So right now, my prolactin is at 5 nanograms per milliliter. Now, this was taken, as you see here, where's the date? Collected 9:25 at 7:33 in the morning. This is reported 9:26 at 2:36 in the
Speaker A
morning, and my prolactin is 5 nanograms per milliliter. It is now October 3rd, so it's been six or eight days or so. I have continued the regimen that took my prolactin down to five, which is ultra low. Usually, guys sit between 10 and 15
Speaker A
nanograms per milliliter. You know, if you look at a lot of labs, that's kind of where guys are typically sitting. So now it's entirely possible that the prolactin is sitting at 3.5, maybe 4, 4.6, something to this effect. And so far, with
Speaker A
extremely low prolactin, and especially like in the last 7 days, which would indicate that it's actually gone a lot lower than five or a little bit lower than five, sexual function has been really the best that's ever been my
Speaker A
entire life. I'm a 40-year-old man on TRT, and the refractory period is extremely low too. So let's talk about all that. Okay, so number one, why I wanted to lower prolactin down into the single digits. The sole answer to this question is in
Speaker A
consultations with real men, I have seen stubborn sexual issues go away when prolactin went down to the single digits. Not that I had any major sexual issues that I wasn't in control of or could manipulate, but I wanted to see what would happen in
Speaker A
terms of refractory period, like how long I could, you know, have sex and then like the period after, like would I be interested in sex 2 hours later, 3 hours later, 5 hours later, an hour later, like how low could I actually get that
Speaker A
period? I wanted to identify whether or not there would be an erection quality or erection firmness enhancement from having lower prolactin than what my baseline typically is. I wanted to see if it would trigger any of the additional
Speaker A
mental libido side of things because prolactin being low will allow hypothalamic dopamine to flow through correctly, and low enough prolactin actually allows the limbic system to fire uninhibited. The limbic system is predominantly where your libido sits, my friends, the medial preoptic hypothalamus.
Speaker A
How I did this? Okay, how did I get my prolactin down to five and now probably like 3.5, 4 point something? I have, I had been, have been dosing P5P. Okay, that is pyridoxal 5 phosphate. That's the
Speaker A
biologically active form of vitamin B6. So when you ingest B6 and when it ultimately converts to being active, it ends up being P5P. So I've been dosing P5P 100 to 200 milligrams, want to say four, five times a week weekly. I don't
Speaker A
necessarily think that I personally have to cycle it. There is some literature out there that suggests neuropathy-like symptoms when taking too much P5P in the presence of a GABAergic deficiency. The mechanism for some of the
Speaker A
neuro, neuropathic symptoms are in fact GABA inhibition or GABA deficiency issues. Okay, so I don't, I don't have that. I don't have to be concerned with that. I consume plenty of probiotics that have strains in them that actually build GABA
Speaker A
from the gut perspective up. All right, but that may be something, you know, some of you want to think about if you're really interested in understanding P5P. Watch the full breakdown I did on that and that GABAergic mechanism on YouTube.
Speaker A
I'll flash the video in front of the screen for you. Now the second and most important thing, which is kind of a curveball strategy that not a lot of people know about but you'd find in the literature, that I did to substantially
Speaker A
lower my prolactin is I blocked the estrogen-induced prolactin release in the pituitary via taking Chandra. Okay, Chandra, this is the bottle here. This is the supplement that I've been taking. I'm running 950 mg of it
Speaker A
a day now. You want Chandre Chinensis. There may be other types of Chandra, but you want to make sure that you're getting that. I mean, a safe bet would actually get the Wild Harvest supplement. This is the stuff that I'm
Speaker A
taking. So this stuff, in addition to inhibiting some of the estradiol-induced prolactin, which by the way, estrogen is very, very progenic in susceptible, I think anyway, regardless, but in susceptible people like a weak pituitary, I don't know, obviously [ __ ]
Speaker A
spam, stop calling me. What they actually isolated is that one of the compounds called gansin N reduces the mRNA and the protein levels of PRL, which is prolactin, in GH3 cells. These were hyperprolactinemic
Speaker A
rats. Want to suggest that, you know, Chandra in and of itself or by itself may be a good treatment for hyperprolactinemia states in which prolactin is higher than it should be. Now here's a paper that kind of explains what's happening at the
Speaker A
estrogen receptor level where Chandra actually regulates the activity, either the binding affinity or the functionality of receptors in a way which probably prevents the genetic overactivation of estrogen-like responses. There were growth factors in the estrogen receptor sites, ERb and ER,
Speaker A
that were inhibited from Chandra. So what this ultimately means is taking Chandra will prevent estradiol induction of prolactin release because ultimately prolactin comes from these cells called lactotropes, and on the lactotropes there are estrogen receptors. And if you
Speaker A
can modulate those estrogen receptors in a way which does the opposite of potentiation on the genetic activity of estradiol post-receptor binding, well then you'll inhibit the stimulation of the lactotropes which make you secrete prolactin. So that's one of the, this is
Speaker A
one of the most powerful chemicals for people that don't have hardcore conditions in which prolactin is very high but prolactin may still be high and you want to lower it to lower prolactin. All right, so number two was I blocked the
Speaker A
estrogen-produced prolactin release in the pituitary via taking Chandra, and the number thre-
Speaker A
having my uh estral number sitting at around 30 pgr per milliliter which is where I kind of usually have it 25 to 30 these days at least I took it back down to where it used to be used to be which was between
Speaker A
18 and 25 picograms per Mill okay and that was using a drug called anastrozol okay that's an aritas inhibitor all right now let's talk about how I feel what are the effects of having five nanograms per milliliter and
Speaker A
probably less right now level of prolactin now let's go back to this guy connected draft on Reddit who says you know this is my issue now low testosterone and low prolactin doctors has never seen it before so of course
Speaker A
I'm looking found nothing you know this guy thinks he has an issue what the real issue probably is is that you know low testosterone in this particular case is going to ultimately mean low lower estrad which is going to mean lower
Speaker A
stimulation of the lactotropes and less prolactin now there's other mechanisms beside estrad that or estrogen that make prolactin secrete but in this particular case that's probably why he has it maybe there's a degree of hypo pituitarism that is taking place where the hormones
Speaker A
that are pumping out from the pituitary gland are not coming out in adequate quantities for that person but that's like you that's where people get this confused I want to make this clear the really are no side effects there's no
Speaker A
disease states in the scientific literature and there's really no correct or accurate anecdotal reporting of negatives associated with between 1 and 5 n per milliliter of prolactin this is serum prolactin only one test for prolactin not sensitive or Ultra
Speaker A
sensitive it's just serum prolactin how I feel okay so number one uh refractory period is definitely lower okay so you know if I needed to in the course of a day I could have sex intercourse through up to three times now for the record uh
Speaker A
climaxing would be a little difficult in the third session possibly a little difficult in the second session but a lot more difficult in the third session and that is because either way when you're inhibiting prolactin if you do
Speaker A
climax as a guy so if you ejaculate you are going to force a little bit of prolactin release even if you're inhibiting it now this depends on the degree of inhibition really the strength of inhibition that you're executing so
Speaker A
if you had something like cabergoline or prol in the mix or like another dopamine Agonist like bromocryptine then the refractory period would would be lower and that post climax rise in prolactin wouldn't be as significant let's capitalize this energetic as [ __ ]
Speaker A
I feel great I honestly feel great I I do not have low estrog like symptoms cuz my yester I was sitting at 22 last time I I looked I don't have like you know this kind of Internet mythological idea
Speaker A
of uh like you know low prolactin symptoms like tiredness Andor anxiety you know one of the postulations out there about low prolactin is that it might interfere with your ability to deal with anxiety it has not there are
Speaker A
plenty of other mechanisms and kind of fail safes that are in place in the brain particularly that deal with anxiety predominantly Gaba inhibiting other excitatory neurotransmitters like glutamate you know but also whether or not your cortisol is regulated whether
Speaker A
or not you go to the gym and work out you know like whe whether or not you're sleeping well whether or not your testosterone levels are high whether or not you have adequate levels of dopamine whether or not you have adequate levels
Speaker A
of acetylcholine and serotonin all this stuff plays like a significant role in anxiety also estrad you know higher the estrogen you go you know the more anxiety you're going to have past a certain threshold so keep that in mind
Speaker A
guys that are on trt so energetic as [ __ ] uh do not have anxiety at any level okay I feel completely fine I feel cool calm balanc like I normally do but I will say on the sexual side I uh I am
Speaker A
having or have uh invasive sexual thoughts okay you know I'm thinking about sex uh certainly more than usual now that the prolactin is lower than I believe it's ever been for me personally I wouldn't call them invasive in a negative way but it's just
Speaker A
like you know picture a typical horny man right like that just thinks about sex every whatever however many times and may have a two or three hour stint work all he's really thinking about his sex and maybe interacting with women in
Speaker A
his life about it or whatever you know that that kind of stuff is basically happening to me you know at at this level I'm not complaining about it I really it's not a bother you know you know it's like you maybe I'd rather be
Speaker A
thinking about something else like you know I may need to get worked on or something but really hasn't interfered with like my capacity to do some of the stuff that I do on a daily basis my friends right so uh that's essentially
Speaker A
it okay lower refractory period very markedly and noticeably energetic as hell as usual nothing really change there uh do not have anxiety so at least for me personally and clients that I've seen as well this myth that prolactin
Speaker A
somehow controls anxiety it like factors out you know all these other mechanisms like Gaba like serotonin like cortisol Etc that control your anxiety like hormones like specifically asrad and testosterone and you know I'm having a good degree of sexual thoughts one may
Speaker A
consider them invasive one may consider them pleasurable you know it all depends on how you look at it it's really not bothering me preventing any productivity and it's super interesting uh I I you know as far as erection quality goes
Speaker A
erection quality perhaps a bump you know perhaps a bit better but I mean again I've done so many things and I ongoingly do a lot of things from vacuum pumps to using the Phoenix to every now and then
Speaker A
I know maybe 2x a week or something all low dose kind of Maintenance dose uh pd5 Inhibitors I think like you know constant blood flow is a great thing like you know if at all morning erections and or nocturnal wood like
Speaker A
dials back at all all I jump on it right away and just like you know bringing something into the regimen that brings it right back so erection quality may be a bit better but certainly libido I could go down I mean that's essentially
Speaker A
part part of uh number four but libido is extremely high okay so what does this say okay this says you know here here's a good strategy to lower prolactin assuming that you don't have tutri adoma or that your pracon is in Sky Sky High
Speaker A
from a opioid receptor Agonist P5 100 to 200 milligram four to five times weekly about 1,000 Mig of chiandra a day and then having the estrog between 18 and 25 picograms per milliliter I mean that that that's a good template for lowering
Speaker A
prolactin in most cases like you don't necessarily have to take Calene or any of these stronger drugs especially if you're concerned about some of the side effects of taking them all right as I said in the beginning coupon code 15 now
Speaker A
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Speaker A
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Speaker A
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Speaker A
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Speaker A
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Speaker A
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Topics:prolactinlow prolactintestosterone replacement therapyTRTsexual functionlibidoP5Pvitamin B6Chandraestrogen receptor
