Speaker A
I did a genetic test with 10X.
Gary Brecka reveals his 10X genetic methylation test results with Dr. Carrie Sarda, explaining gene variants and their health impacts.
Key Takeaways
- Methylation is a critical biochemical process impacting multiple health aspects.
- Gene variants can reduce methylation efficiency but can be managed with targeted supplements.
- Genetic testing can reveal actionable insights for personalized health optimization.
- Severe methylation disruptions are linked to serious mental and physical health conditions.
- Functional medicine approaches can effectively address gene-related health challenges.
Summary
- Gary Brecka undergoes a 10X genetic methylation test to analyze five key methylation genes.
- Dr. Carrie Sarda explains the significance of methylation in converting nutrients into usable forms.
- Genetic variants are categorized by color: green (normal), yellow (one variant), red (two variants).
- Gary’s results show mostly green and one yellow variant, indicating good gene function with minor inefficiency.
- Methylation affects sleep, thyroid, gut health, mood, detoxification, inflammation, and free radical defense.
- Supplementing with activated nutrients like methylated B12 can compensate for gene variants.
- Severe methylation gene disruptions correlate with mental illnesses, addiction, sleep disorders, and gut issues.
- Functional medicine and targeted supplementation can significantly improve or remediate symptoms.
- The test provides actionable genetic data rather than non-actionable physical traits.
- Understanding gene variants allows personalized health interventions to optimize overall wellbeing.
Full Transcript — Download SRT & Markdown
Speaker B
You did?
Speaker A
I did. And um, like you said, you're not able to give me the results of my test.
Speaker A
But I wanted to invite in Dr. Carrie Sarda, who's going to give me those results now. And she's going to explain a little bit to me about my results and also what the test is and what it means for me. So, I'm very excited to see the results.
Speaker B
I'm excited for you to see them.
Speaker B
Let's get her in.
Speaker A
A couple of days ago, I had someone come to my studio and they did a swab inside of my mouth for something called the 10X genetic methylation test, I believe.
Speaker A
What was that test?
Speaker A
And why did I do it?
Speaker B
You did it to look at the
Speaker B
five major genes of methylation.
Speaker B
So remember that if we pulled your entire genetic code, we would get a lot of non-actionable information. I could see that you have dark olive skin, you have dark eyes, you have detached your earlobes, but there's nothing you can do with that genetic information.
Speaker B
We want genetic information that's actionable.
Speaker B
So while you can't go in and fix the gene,
Speaker B
you can very often supplement for its function.
Speaker B
And the genes of methylation are very special because they code for the process of converting one raw material
Speaker B
into the usable form.
Speaker B
So in other words, we take in folic acid or its derivatives, but we convert it into a usable form called methylfolate.
Speaker B
And so this process is called methylation.
Speaker B
It's one of the most important process that human beings go through.
Speaker B
We do it 300 billion times a day.
Speaker B
And when you have breaks in certain genes,
Speaker B
this means that your body is not converting one raw material into the usable form.
Speaker B
And this causes a deficiency.
Speaker B
And very often it's this deficiency that leads to some of the most common ailments that we suffer from.
Speaker A
Dr. Carrie Sarda.
Speaker C
Hello.
Speaker C
Thanks for having me.
Speaker A
Could you give us a little bit of your bio and your background?
Speaker C
Sure. I my original training was surgical.
Speaker C
It was obstetrical and gynecology.
Speaker C
And I just found that um, more chronic disease was happening.
Speaker C
And people weren't really getting better.
Speaker C
And so my specialized training has been in functional medicine, kind of a more holistic approach.
Speaker C
I have two master's degrees in this.
Speaker C
And met up with um,
Speaker C
Mr. Breca.
Speaker B
Eight years ago.
Speaker B
Now.
Speaker B
It's been a while.
Speaker C
It's been a while.
Speaker C
And in a small room and and we started up um,
Speaker C
looking at these genetic tests and reasons that people were not getting better.
Speaker A
So I've got my test results here, which full disclosure, I'm yet to see.
Speaker C
So Jack over here is
Speaker A
So Jack over here is
Speaker C
put them on my iPad.
Speaker A
put them on my iPad.
Speaker C
And told me that I can swipe up and look at them.
Speaker A
And told me that I can swipe up and look at them.
Speaker A
So what am I looking at here?
Speaker A
And what does it tell me?
Speaker C
Okay, so with your permission
Speaker C
that we can share that, of course.
Speaker A
Only if it's good.
Speaker A
I'm joking.
Speaker C
That's important.
Speaker C
Well, I do.
Speaker C
I do want to tell you, your your parents did you a solid.
Speaker B
Yeah, they did.
Speaker B
You won the genetic lottery.
Speaker C
So remember that in genetics,
Speaker C
I think people get confused.
Speaker C
Genes are like blueprints.
Speaker C
So your mother writes half of that blueprint.
Speaker C
And your father writes the other half.
Speaker C
And you're born with that.
Speaker C
You'll take that to your grave.
Speaker C
So when you do have something that isn't quite exactly what you want it to be,
Speaker C
variant is the term that we tend to use.
Speaker C
When that does happen, we want to find out ways to work around that.
Speaker C
How we color code this to make it understandable is if you have a kind of a normal copy and a normal copy from each parent,
Speaker C
that's green.
Speaker C
And if you have one copy from a parent that is normal, but one copy that is not,
Speaker C
we're going to color that yellow.
Speaker C
And you have one of those.
Speaker C
And if you have both copies are not normal, that's red.
Speaker C
And you don't have any of those,
Speaker C
which is great.
Speaker C
And the significance to that is the green genes will code 100%.
Speaker C
You're good to go.
Speaker C
Yellow genes about 40%.
Speaker C
Red genes 10 or less.
Speaker C
And so kind of think of it like putting spokes in a wheel.
Speaker C
It just kind of clogging it up.
Speaker C
Because these genes do follow a pathway.
Speaker C
It's the methylation pathway.
Speaker C
I like to think of methylation as activation.
Speaker C
Like we talked about taking something raw, bring it in and allowing your cells to convert it to what it can use.
Speaker C
So if you have any glitches in the pathway, you're not going to be as efficient.
Speaker C
So you would want to correct for your one variant gene there.
Speaker C
So you come in nicely with that first gene, that's probably the most common one and that's the real popular one.
Speaker C
Um, we kind of take it next level.
Speaker C
We follow the pathway all the way up.
Speaker C
And the reason why this even matters is because it affects everything on you.
Speaker C
It affects how you sleep.
Speaker C
It affects ultimately,
Speaker C
down the road.
Speaker C
At a deeper level.
Speaker C
How you sleep.
Speaker C
How your thyroid functions, how your gut functions.
Speaker C
How your moods.
Speaker C
How you detox, especially heavy metals.
Speaker C
How you detox.
Speaker C
It affects your inflammation in your body.
Speaker C
How well you can fight free radicals.
Speaker C
Those are all important things.
Speaker C
And that's why this is more than just data.
Speaker C
Um, it's real data.
Speaker C
So for if you do not correct your one yellow,
Speaker C
you're not going to be as good at doing all those things.
Speaker C
Detoxing, fighting inflammation.
Speaker C
Your gut movement.
Speaker C
Those kinds of things.
Speaker C
And it's a pretty simple fix for you.
Speaker C
If you don't activate activate those nutrients,
Speaker C
then let's give you activated nutrients.
Speaker C
For example,
Speaker C
you most likely have trouble activating B12.
Speaker C
That's probably an issue that that you're not as efficient at.
Speaker C
Of course you do it.
Speaker C
But you're not as efficient at it.
Speaker C
Because it wasn't green.
Speaker C
So we you would want to therefore take the activated B12 form, the methylated B12 form.
Speaker C
So by doing that every day, I kind of liken it to the road is broken, but you've built a bridge over it.
Speaker C
So that's how you can um, compensate for that.
Speaker C
Gene variant or that gene break.
Speaker C
We like to kind of lovingly call them.
Speaker A
On my results, it says one parent passed on a gene mutation.
Speaker A
Which one was it?
Speaker C
So that's right.
Speaker C
So so that's that's
Speaker B
You want to know who to blame.
Speaker C
So that's the thing.
Speaker C
Unless you tested your parents, you're not going to really know who gave you what.
Speaker A
Okay.
Speaker C
You do know that you had one that gave you a normal gene and one that gave you a variant.
Speaker C
And that's why it's yellow.
Speaker A
What else does this mean for me on a practical level?
Speaker A
Does this mean that I'm going to like, you know, I want to know if there's any sort of health implications that I should be aware of?
Speaker C
So anytime you have any kind of variant in your methylation, especially in the lower pathway,
Speaker C
you have to understand that it is going to affect it all the way up.
Speaker C
So when so effects can be all the way from simple sleep issues to all the way to not being able to sleep at all.
Speaker C
Uh, can be mood, uh, gut issues.
Speaker A
Okay.
Speaker B
But you can take it out of the loop with the supplement.
Speaker A
Are you able to tell me about the worst sort of profile you've seen?
Speaker A
And the sort of real world consequences of that when all five markers of their
Speaker B
are are interrupted.
Speaker B
Yeah, we've seen them where
Speaker B
there's a heavy mix of red and green.
Speaker A
Okay.
Speaker B
Um, and this is where you see significant um, personality alterations, significant um,
Speaker B
what we would refer to as mental illness, severe ADD, ADHD, OCD,
Speaker B
manic depression, bipolar.
Speaker B
Um, you see very high propensities for addiction because of the depleted level of dopamine.
Speaker B
Um, you see significant sleep disorders, um, very severe gut issues, gas, bloating, diarrhea, constipation, irritability, cramping that don't seem to be fixable with conventional therapies or dietary changes.
Speaker B
Um, those are amazing cases to watch the clinical team work with because
Speaker B
by getting methylation right, I have seen those cases solved by our clinical team.
Speaker B
And and and many of those symptoms become fully remissive.
Speaker B
And we get a lot of chances to make good people great.
Speaker B
But when you can materially change somebody's life, um,
Speaker B
by fixing those gene mutations,
Speaker B
that's when you're really making an impact.
Speaker A
These five acronyms here, COMT, and then it says mind.
Speaker A
AHCY, then it says mind.
Speaker A
MTRR, then it says upper gut.
Speaker A
MTR, that says lower gut.
Speaker A
That's the one that I have this yellow one on.
Speaker A
And then there's the motherfucker one, I shouldn't say that, the MTHFR, which is mind and gut.
Speaker A
These are the five sort of factors for methylation,
Speaker A
which is really about how I process the ingredients I put in my body.
Speaker B
Yes.
Speaker A
And I'm guessing that these are at different stages in my body.
Speaker A
So the ones that say mind are in my head.
Speaker A
The one that says upper gut is sort of higher up in my gut.
Speaker A
The one that says lower up is in my lower gut.
Speaker A
And then this MTHFR that says mind and gut, that's that's
Speaker B
Yes.
Speaker B
And the reason is that
Speaker B
remember these are sequential.
Speaker A
Okay.
Speaker B
Right?
Speaker B
So
Speaker B
I always use the analogy that think of it like a sandbag pass, right?
Speaker B
So you have a bunch of guys lined up and you have one guy that's taking the sandbags off the truck.
Speaker B
And passing it to the next guy.
Speaker B
And he passes it to the next guy and so on.
Speaker B
Well, if if early in that chain, he was supposed to take 10 sandbags off the truck.
Speaker B
But he dropped four.
Speaker B
The best the rest of the line could do is six.
Speaker B
So in other words, if an early gene like MTHFR, which is early in the methylation cycle is impaired,
Speaker B
it impairs the entire downstream.
Speaker B
And if several gene snips later, you have another major gene snip, it will impair things further downstream.
Speaker A
Ah, so is that what you tend to see if someone has the
Speaker B
Yes.
Speaker B
This is why if you Google consequences of MTHFR or MTHFR and um, miscarriages, MTHFR and ADD, MTHFR and ADHD, MTHFR and anxiety.
Speaker B
You're going to see hordes of articles and and clinical studies
Speaker B
linking that gene mutation to what seems like a vast myriad of consequences.
Speaker B
Well, that vast myriad of consequences is actually related to the gene snips that are further downstream.
Speaker B
But they're affected because they're not getting the raw material they need to do their job.
Speaker B
And and in my opinion, it's one of the most overlooked things in all of modern medicine.
Speaker B
As simple as this test is and is easily and widely available as it is.
Speaker B
I'm surprised that more frontline clinics do not do this.
Speaker B
Because people do it once in their lifetime.
Speaker B
And they supplement for deficiency.
Speaker B
And sometimes you see miraculous changes in their life.
Speaker A
Gary, thank you.
Speaker A
I'm going to put this these results, my results in the description of this episode below, exactly as it is here in front of me.
Speaker A
So everyone can see and the details of how I got the test done, etc.
Speaker A
will all be available there for you guys to to check out.
Speaker A
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Speaker A
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Speaker A
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Topics:Gary BreckaSteven Bartlett10X genetic testmethylationgene variantsfunctional medicinegenetic testinghealth optimizationmethylated B12chronic disease
